The Wild Card round begins with a road favorite, as the point spread has increased from its opening line of 2.5. Houston won last year as a home underdog in the playoffs.
Baltimore and Pittsburgh meet for the third time this season, as Lamar Jackson and the Ravens begin their quest to get over the hump and reach the Super Bowl.
This point spread opened at 17 and has gradually moved up, now representing the largest spread all season. Baltimore needs to win to clinch the AFC North, while Bailey Zappe will start at quarterback for Cleveland.
Cincinnati has won and covered four straight games, while Pittsburgh is riding a three-game losing skid. As for the playoffs, the Bengals need a win and some help to make it.
Buffalo quarterback Josh Allen is the NFL MVP betting favorite with -320 odds. Reigning MVP Lamar Jackson is the second favorite with +225 odds and plays on national television on Saturday.
The Hokies are expected to be short-handed, missing as many as 14 of their 22 starters. Meanwhile, the Gophers are only expected to have a handful opt out of this Mayo Bowl.