PICK: Steelers at Bengals (-3) 🎥
Pittsburgh since in first place in the AFC North but 4-7 Cincinnati is the home favorite.
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PICK: Eagles at Ravens (-3) 🎥
Lamar Jackson is 23-1 in his career against NFC teams but Philly is undefeated this season with wide receiver A.J. Brown in the lineup.
PICK: 49ers at Bills (-6) 🎥
San Francisco is still mathematically alive for the playoffs and will get Brock Purdy back from injury. Meanwhile, Josh Allen is the MVP favorite and Buffalo is pursuing the AFC's top seed.
PICK: #3 Ohio St. (-19.5) hosts Michigan 🎥
This rivalry has gone over the total in 10 straight meetings. This year's total is 42.5, while the Buckeyes are also huge favorites.
PICK: #5 Notre Dame (-7.5) at USC 🎥
The Fighting Irish face pressure with a playoff berth on the line with a victory. Meanwhile, USC has held a fourth-quarter lead in all five of its losses.
PICK: #3 Texas (-5.5) at #20 Texas A&M 🎥
The winner of this rivalry game advances to the SEC title game to face #7 Georgia. Plus, underdogs are 41-17-1 ATS in SEC play this season.
PICK: Chiefs (-13) host Raiders 🎥
Kansas City has failed to cover in five straight games, and four those have come as a favorite of at least seven points.
PICK: Miss. St. at #14 Ole Miss (-24.5) 🎥
The Rebels are coming off a crippling loss that likely knocked them out of the college football playoff. Meanwhile, the Bulldogs are winless in SEC play.
PICK: #9 Georgia (-17.5) hosts Georgia Tech 🎥
The Bulldogs are guaranteed a spot in next week's SEC title game so will that impact their performance as a big favorite? Georgia is just 3-8 ATS this season.
PICK: Dolphins at Packers (-3.5) 🎥
This spread moved from 3 to 3.5 on Wednesday night. Tua Tagovailoa is winless in seven NFL starts when the temperature is 40 degrees or below.